RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Asic2
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
In Silico Identification of miRNA Binding Sites; Measurement of Cytokines and Collagen Content etc.
Target
Tgf-beta1; Ets1
Pathway
NA
PubMed ID
Title
MicroRNA-326 Regulates Profibrotic Functions of Transforming Growth Factor-B in Pulmonary Fibrosis
Year
2014
Function
"Hsa-miR-326 regulates TGF-B1 expression and that hsa-miR-326 levels are inversely correlated to TGF-B1 protein levels in multiple human cell lines.MiR-326 was found to down-regulate profibrotic genes, such as Ets1, Smad3, and matrix metalloproteinase 9, whereas it up-regulates antifibrotic genes, such as Smad7."